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Review
. 2009 May 10;27(14):2308-18.
doi: 10.1200/JCO.2009.22.3339. Epub 2009 Apr 13.

The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research

Leslie L Robison  1 , Gregory T Armstrong, John D Boice, Eric J Chow, Stella M Davies, Sarah S Donaldson, Daniel M Green, Sue Hammond, Anna T Meadows, Ann C Mertens, John J Mulvihill, Paul C Nathan, Joseph P Neglia, Roger J Packer, Preetha Rajaraman, Charles A Sklar, Marilyn Stovall, Louise C Strong, Yutaka Yasui, Lonnie K Zeltzer
Affiliations
Review

The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research

Leslie L Robison et al. J Clin Oncol. .

Abstract

Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors.

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Conflict of interest statement

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

Figures

Fig 1.
Fig 1.
Childhood Cancer Survivor Study consortium centers.
Fig 2.
Fig 2.
Childhood Cancer Survivor Study organizational structure. NCI, National Cancer Institute.
Fig 3.
Fig 3.
Geographic distribution of survivors participating in the Childhood Cancer Survivor Study.
Fig 4.
Fig 4.
Chronology of Childhood Cancer Survivor Study surveys and specimen collection.
Fig 5.
Fig 5.
Process for requesting access to the Childhood Cancer Survivor Study (CCSS) resource for analysis and publication.
See this image and copyright information in PMC

References

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