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Review
. 2009 May;19(5):532-45.
doi: 10.1038/cr.2009.41.

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis

Shih-Lei Lai  1 , Andy J Chien, Randall T Moon
Affiliations
Review

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis

Shih-Lei Lai et al. Cell Res. 2009 May.

Abstract

Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. Beta-catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both beta-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.

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