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Comment
. 2009 Apr 14;6(4):e1000054.
doi: 10.1371/journal.pmed.1000054. Epub 2009 Apr 14.

Mapping the spread of malaria drug resistance

Tim Anderson  1
Affiliations
Comment

Mapping the spread of malaria drug resistance

Tim Anderson. PLoS Med. .

Abstract

Tim Anderson discusses a new study of molecular variation in alleles at the dihydropteroate synthase locus, which underlies resistance to sulfadoxine, in over 5,000 parasites from 50 locations.

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Conflict of interest statement

The author has declared that no competing interests exist.

Comment on

  • Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.
    Pearce RJ, Pota H, Evehe MS, Bâ el-H, Mombo-Ngoma G, Malisa AL, Ord R, Inojosa W, Matondo A, Diallo DA, Mbacham W, van den Broek IV, Swarthout TD, Getachew A, Dejene S, Grobusch MP, Njie F, Dunyo S, Kweku M, Owusu-Agyei S, Chandramohan D, Bonnet M, Guthmann JP, Clarke S, Barnes KI, Streat E, Katokele ST, Uusiku P, Agboghoroma CO, Elegba OY, Cissé B, A-Elbasit IE, Giha HA, Kachur SP, Lynch C, Rwakimari JB, Chanda P, Hawela M, Sharp B, Naidoo I, Roper C. Pearce RJ, et al. PLoS Med. 2009 Apr 14;6(4):e1000055. doi: 10.1371/journal.pmed.1000055. Epub 2009 Apr 14. PLoS Med. 2009. PMID: 19365539 Free PMC article.

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References

    1. Hayton K, Su XZ. Genetic and biochemical aspects of drug resistance in malaria parasites. Curr Drug Targets Infect Disord. 2004;4:1–10. - PubMed
    1. Kublin JG, Cortese JF, Njunju EM, Mukadam RA, Wirima JJ, et al. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis. 2003;187:1870–1875. - PubMed
    1. Gregson A, Plowe CV. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev. 2005;57:117–145. - PubMed
    1. Pearce RJ, Pota H, Evehe M-SB, Bâ E-H, Mombo-Ngoma G, et al. Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PLoS Med. 2009;6:e1000055. doi:10.1371/journal.pmed.1000055. - PMC - PubMed
    1. Hartl DL, Clark AG. Sunderland (MA): Sinauer Associates; 2007. Principles of population genetics. p. 542.

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