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Review
. 2009;85(4):143-56.
doi: 10.2183/pjab.85.143.

Pathogen recognition by innate immunity and its signaling

Shizuo Akira  1
Affiliations
Review

Pathogen recognition by innate immunity and its signaling

Shizuo Akira. Proc Jpn Acad Ser B Phys Biol Sci. 2009.

Erratum in

  • Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(6):216

Abstract

Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

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Figures

Fig. 1
Fig. 1
Principal of immune response.
Fig. 2
Fig. 2
Innate immunity and adaptive immunity. NK: natural killer; LN: lymphnode.
Fig. 3
Fig. 3
Pathogen recognition and immune responses.
Fig. 4
Fig. 4
Interaction between dendritic cells and T cells.
Fig. 5
Fig. 5
Induction of tumor immunity by TLRs stimulation.
Fig. 6
Fig. 6
Myeloid differentiation (MyD) genes in hematopoietic differentiation.
Fig. 7
Fig. 7
Toll-like receptors comprise a superfamily with IL-1Rs.
Fig. 8
Fig. 8
TLR family and its ligands.
Fig. 9
Fig. 9
MyD88-dependent and TRIF-dependent pathways in TLR signaling.
Fig. 10
Fig. 10
MyD88-dependent type I interferon production in plasmacytoid dendritic cells.
Fig. 11
Fig. 11
Cytoplasmic pathogen sensors and anti-viral responses.
See this image and copyright information in PMC

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References

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