Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009;85(4):143-56.
doi: 10.2183/pjab.85.143.

Pathogen recognition by innate immunity and its signaling

Shizuo Akira  1
Affiliations
Review

Pathogen recognition by innate immunity and its signaling

Shizuo Akira. Proc Jpn Acad Ser B Phys Biol Sci. 2009.

Erratum in

  • Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(6):216

Abstract

Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Principal of immune response.
Fig. 2
Fig. 2
Innate immunity and adaptive immunity. NK: natural killer; LN: lymphnode.
Fig. 3
Fig. 3
Pathogen recognition and immune responses.
Fig. 4
Fig. 4
Interaction between dendritic cells and T cells.
Fig. 5
Fig. 5
Induction of tumor immunity by TLRs stimulation.
Fig. 6
Fig. 6
Myeloid differentiation (MyD) genes in hematopoietic differentiation.
Fig. 7
Fig. 7
Toll-like receptors comprise a superfamily with IL-1Rs.
Fig. 8
Fig. 8
TLR family and its ligands.
Fig. 9
Fig. 9
MyD88-dependent and TRIF-dependent pathways in TLR signaling.
Fig. 10
Fig. 10
MyD88-dependent type I interferon production in plasmacytoid dendritic cells.
Fig. 11
Fig. 11
Cytoplasmic pathogen sensors and anti-viral responses.
See this image and copyright information in PMC

References

    1. Akira S., Uematsu S., Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell 24, 783–801 - PubMed
    1. Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., et al. (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9, 1897–1906 - PMC - PubMed
    1. Akira S., Nishio Y., Inoue M., Wang X., Wei S., Matsuzaka T., et al. (1994) Molecular cloning of APRF, a novel ISGF3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63–71 - PubMed
    1. Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., et al. (1996) STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci., USA 93, 3963–3966 - PMC - PubMed
    1. Muzio M., Ni J., Feng P., Dixit V.M. (1997) IRAK(Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612–1615 - PubMed