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. 2009 May 21;11(10):2109-12.
doi: 10.1021/ol900567c.

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: a new difluoromethylation reagent for S-, N-, and C-nucleophiles

Wei Zhang  1 , Fei Wang, Jinbo Hu
Affiliations

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: a new difluoromethylation reagent for S-, N-, and C-nucleophiles

Wei Zhang et al. Org Lett. .

Erratum in

  • Org Lett. 2013 Nov 1;15(21):5613

Abstract

The first alpha-difluoromethyl sulfoximine compound, 2, was successfully prepared by using the copper(II)-catalyzed nitrene transfer reaction. Compound 2 was found to be a novel and efficient difluoromethylation reagent for transferring the CF(2)H group to S-, N-, and C-nucleophiles. Deuterium-labeling experiments suggest that a difluorocarbene mechanism is involved in the current difluoromethylation reactions.

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