Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 May 15;19(10):2780-4.
doi: 10.1016/j.bmcl.2009.03.110. Epub 2009 Mar 27.

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

John Porter  1 , Simon Lumb, Richard J Franklin, Jose M Gascon-Simorte, Mark Calmiano, Kelly Le Riche, Bénédicte Lallemand, Jean Keyaerts, Helen Edwards, Alison Maloney, Jean Delgado, Lloyd King, Anne Foley, Fabien Lecomte, James Reuberson, Christoph Meier, Mark Batchelor
Affiliations

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

John Porter et al. Bioorg Med Chem Lett. .

Abstract

A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.

PubMed Disclaimer

MeSH terms

LinkOut - more resources