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Comment
. 2009 Apr 16;458(7240):E8-9; discussion E9-10.
doi: 10.1038/nature07916.

Tbx18 and the fate of epicardial progenitors

Vincent M Christoffels  1 , Thomas Grieskamp, Julia Norden, Mathilda T M Mommersteeg, Carsten Rudat, Andreas Kispert
Affiliations
Comment

Tbx18 and the fate of epicardial progenitors

Vincent M Christoffels et al. Nature. .

Abstract

Uncovering the origins of myocardial cells is important for understanding and treating heart diseases. Cai et al. suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.

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Comment on

  • A myocardial lineage derives from Tbx18 epicardial cells.
    Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. Cai CL, et al. Nature. 2008 Jul 3;454(7200):104-8. doi: 10.1038/nature06969. Epub 2008 May 14. Nature. 2008. PMID: 18480752 Free PMC article.

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