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. 2009;7(1):1-8.
doi: 10.3390/md7010001. Epub 2008 Dec 28.

Cytotoxic aaptamines from Malaysian Aaptos aaptos

Khozirah Shaari  1 , Kee Cheng Ling, Zalilawati Mat Rashid, Tan Pei Jean, Faridah Abas, Salahudin Mohd Raof, Zurina Zainal, Nordin Hj Lajis, Habsah Mohamad, Abdul Manaf Ali
Affiliations

Cytotoxic aaptamines from Malaysian Aaptos aaptos

Khozirah Shaari et al. Mar Drugs. 2009.

Abstract

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

Keywords: Aaptos aaptos; Marine sponge; aaptaminoids; alkaloids; cytotoxicity.

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References

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