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. 2009 Apr 15;2009(2):CD007523.
doi: 10.1002/14651858.CD007523.pub2.

Honey and lozenges for children with non-specific cough

Affiliations

Honey and lozenges for children with non-specific cough

Selamawit Mulholland et al. Cochrane Database Syst Rev. .

Abstract

Background: Chronic non-specific cough is a chronic, dry cough of in the absence of identifiable respiratory disease or known aetiology. Although it is usually not reflective of an underlying severe illness, it does cause significant morbidity, and as such relief from it is often sought. The use of honey and lozenges to soothe upper respiratory tract irritation is common, inexpensive, and potentially more effective in treating the symptoms than pharmacological interventions.

Objectives: To evaluate the efficacy of honey and/or lozenges in the management of children with chronic non-specific cough.

Search strategy: The Cochrane Airways Group searched the Cochrane Register of Controlled Trials (CENTRAL), MEDLINE, OLDMEDLINE, and EMBASE databases in October 2008.

Selection criteria: All randomised controlled trials comparing honey or lozenges with a placebo in treating children with chronic non-specific cough.

Data collection and analysis: The results of the searches were assessed according to the pre-determined criteria. None of the trials identified by the searches were eligible for inclusion, leaving no data available for analysis in this review.

Main results: The search did not provide any applicable randomised controlled trials that investigated the efficacy of honey and lozenges in treating children with non-specific chronic cough. Data from acute studies suggest a potential role for honey in relieving cough, but whether this is applicable to chronic cough is unknown.

Authors' conclusions: Clinically, this review was unable to provide any justifiable recommendation for or against honey and/or lozenges due to the lack of evidence. The absence of applicable studies highlights the need for further research into the area of treating children with chronic non-specific coughs with honey and/or lozenges. These treatments are not recommended when managing very young children (as lozenges are a potential choking hazard, and honey may cause infant botulism in children under 1 year of age).

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Conflict of interest statement

None of the authors have any conflict of interest.

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  • doi: 10.1002/14651858.CD007523

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References

References to studies excluded from this review

Abdul 1999 {published data only}
    1. Abdul Manap R, Wright CE, Gregory A, Rostami‐Hodjegan A, Meller ST, Kelm GR, et al. The antitussive effect of dextromethorphan in relation to CYP2D6 activity. British Journal of Clinical Pharmacology 1999;48(3):382‐7. - PMC - PubMed
Eby 2006 {published data only}
    1. Eby GA, Halcomb WW. Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common‐cold treatment: a double‐blind, placebo‐controlled clinical trial. Alternative Therapies in Health and Medicine 2006;12(1):34‐8. - PubMed
Fischer 2002 {published data only}
    1. Fischer J, Pschorn U, Vix JM, Peil H, Aicher B, Muller A, Mey C. Efficacy and tolerability of ambroxol hydrochloride lozenges in sore throat. Randomised, double‐blind, placebo‐controlled trials regarding the local anaesthetic properties. Arzneimittel‐Forschung 2002;52(4):256‐63. - PubMed
Fujimori 1998 {published data only}
    1. Fujimori K, Suzuki E, Arakawa M. Effects of oxatomide, H1‐antagonist, on postinfectious chronic cough; a comparison of oxatomide combined with dextromethorphan versus dextromethorphan alone. Japanese Journal of Allergology 1998;47(1):48‐53. - PubMed
Gilbert 2008 {published data only}
    1. Gilbert G. Single dose of honey effective for cough in kids. Journal of the National Medical Association 2008;100(4):459.
Grattan 1995 {published data only}
    1. Grattan TJ, Marshall AE, Higgins KS, Morice AH. The effect of inhaled and oral dextromethorphan on citric acid induced cough in man. British Journal of Clinical Pharmacology 1995;39(3):261‐3. - PMC - PubMed
Haidl 2001 {published data only}
    1. Haidl P, Kemper P Sr, Butnarasu J, Klauke M, Wehde H, Kohler D. Influence of the inhalation of a 1% L‐menthol‐solution in the premedication of fiberoptic bronchoscopy on cough and the sensation of dyspnea. Pneumologic 2001;55(3):115‐9. - PubMed
Lee 2000 {published data only}
    1. Lee PC, Jawad MS, Eccles R. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. The Journal of Pharmacy and Pharmacology 2000;52(9):1137‐42. - PubMed
Macknin 1998 {published data only}
    1. Macknin ML, Piedmonte M, Calendine C, Janosky J, Wald E. Zinc gluconate lozenges for treating the common cold in children: a randomized controlled trial. The Journal of the American Medical Association 1998;279(24):1962‐7. - PubMed
Matthys 1983 {published data only}
    1. Matthys H, Bleicher B, Bleicher U. Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough. The Journal of International Medical Research 1983;11(2):92‐100. - PubMed
Mizoguchi 2007 {published data only}
    1. Mizoguchi H, Wilson A, Jerdack GR, Hull JD, Goodale M, Grender JM, Tyler BA. Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. International Journal of Clinical Pharmacology and Therapeutics 2007;45(4):230‐6. - PubMed
Mossad 1996 {published data only}
    1. Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold. A randomized, double‐blind, placebo‐controlled study. Annals of Internal Medicine 1996;125(2):81‐8. - PubMed
Paul 2004 {published data only}
    1. Paul IM, Yoder KE, Crowell KR, Shaffer ML, McMillan HS, Carlson LC, Dilworth DA, Berlin CM, Jr. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004;114(1):85‐90. - PubMed
Paul 2007 {published data only}
    1. Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr. Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 2007;161:1140‐1146. - PubMed
Prasad 2000 {published data only}
    1. Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double‐blind, placebo‐controlled trial. Annals of Internal Medicine 2000;133(4):245‐52. - PubMed
Prasad 2008 {published data only}
    1. Prasad AS, Beck FW, Bao B, Snell D, Fitzgerald JT. Duration and severity of symptoms and levels of plasma interleukin‐1 receptor antagonist, soluble tumour necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. The Journal of Infectious Diseases 2008;197(6):795‐802. - PubMed
Scavino 1985 {published data only}
    1. Scavino Y. Combination therapy in patients with the common cold. Current Therapeutic Research 1985;38(5):746‐54.
Schutz 2002 {published data only}
    1. Schutz A, Gund HJ, Pschorn U, Aicher B, Peil H, Muller A, Mey C, Gillissen A. Local anaesthetic properties of ambroxol hydrochloride lozenges in view of sore throat. Arzneimittel‐Forschung 2002;52(3):194‐9. - PubMed
Taylor 1993 {published data only}
    1. Taylor JA, Novack AH, Almquist JR, Rogers JE. Efficacy of cough suppressants in children. Journal of Pediatrics 1993;122(5 Pt 1):799‐802. - PubMed
Weippl 1984 {published data only}
    1. Weippl G. Therapeutic approaches to the common cold in children. Clinical Therapeutics 1984;6(4):475‐82. - PubMed
Yoder 2006 {published data only}
    1. Yoder KE, Shaffer ML, Tournous SJ, Paul IM. Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. Clinical Pediatrics 2006;45(7):633‐40. - PubMed

Additional references

Britt 2002
    1. Britt H, Miller GC, Knox S, Charles J, Valenti L, Henderson J, et al. Bettering the Evaluation and Care of Health ‐ A Study of General Practice Activity. Australian Institue of Health and Welfare Cat. No. GEP‐10 2002.
Cates 2003 [Computer program]
    1. Cates C. Visual Rx. Online NNT Calculator. http://www.nntonline.net/: Cates C, 2003.
Chang 1999
    1. Chang AB. State of the art: cough, cough receptors, and asthma in children. Pediatric Pulmonology 1999;28:59‐70. - PubMed
Chang 2001
    1. Chang AB, Asher MI. A review of cough in children. Journal of Asthma 2001;38(4):299‐309. - PubMed
Chang 2005
    1. Chang AB. Cough: are children really different to adults?. Cough 2005;1:7. - PMC - PubMed
Chang 2006
    1. AB Chang, WB Glomb. Guidelines for Evaluating Chronic Cough in Pediatrics. Chest 2006;129(1):260S‐83S. - PubMed
Chang 2007
    1. Chang CC, Cheng AC, Chang AB. Over‐the‐counter (OTC) cough medications to reduce cough as an adjunct to antibiotics for acute pneumonia in adults and children. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD006088.pub2] - DOI - PubMed
Cherry 2003
    1. Cherry DK, Burt CW, Woodwell DA. National Ambulatory Medical Care Survey: 2001 summary. Adv Data 2003;337:1‐44. - PubMed
Eccles 2002
    1. R Eccles. The Powerful Placebo in Cough Studies?. Pulmonary Pharmacology and Therapeutics 2002;15:303‐8. - PubMed
Elbourne 2002
    1. Elbourne DR, Altman DG, Higgins JPT, Curtin F, Worthington HV, Vail A. Meta‐analyses involving cross‐over trials: methodological issues. International Journal of Epidemiology 2002;31(1):140‐9. - PubMed
Higgins 2008
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0 [updated Feruary 2008]. The Cochrane Collaboration (Available from www.cochrane‐handbook.org) 2008.
Jüni 2001
    1. Jüni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 2001;232 (7303):42‐6. - PMC - PubMed
Marchant 2008
    1. JM Marchant, PA Newcombe, EF Juniper, JK Sheffield, SL Stathis, AB Chang. Chronic cough in children and its burden on parents. Chest 2008;134:303‐9. - PubMed
Newcombe 2008
    1. PA Newcombe, JK Sheffield, EF Juniper, JM Marchant, Halstead R, Masters IB, AB Chang. Development of a parent‐proxy cough‐specific QOL questionnaire: clinical impact vs psychometric evaluations. Chest 2008;133:386‐395. - PubMed
Paul 2007
    1. IM Paul, J Beiler, A McMonagle, ML Shaffer, L Duda, CM Berlin Jr. Effect of Honey, Dextromethorphan, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents. Archives of Paediatrics and Adolescent Medicine December 2007;161(12):1140‐6. - PubMed
Schroeder 2004
    1. Schroeder K, Fahey T. Over‐the‐counter medications for acute cough in children and adults in ambulatory settings (Cochrane review). Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD001831.pub2] - DOI - PubMed

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