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. 2009 Jun-Jul;44(6-7):372-4.
doi: 10.1016/j.exger.2009.04.001. Epub 2009 Apr 14.

The somatotropic axis and aging: mechanisms and persistent questions about practical implications

Andrzej Bartke  1
Affiliations

The somatotropic axis and aging: mechanisms and persistent questions about practical implications

Andrzej Bartke. Exp Gerontol. 2009 Jun-Jul.

Abstract

Reduced somatotropic (GH/IGF-1) signaling delays aging and extends longevity in laboratory mice. However, it is unclear whether the physiological decrease of GH and IGF-1 levels with age represents a symptom of declining neuroendocrine function, a cause of age-related alterations in body composition and functionality or a protective mechanism against age-associated disease. Although available clinical evidence does not support the use of recombinant GH as an anti-aging therapy, many studies suggest the potential utility of GH and GH secretagogues in the treatment of sarcopenia and frailty.

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References

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