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. 2009 Aug-Sep;24(4):349-52.
doi: 10.1177/1533317509333040. Epub 2009 Apr 16.

ApoE genotype and family history in patients with dementia and cognitively intact spousal controls

Maria Zintl  1 , Gerd Schmitz, Göran Hajak, Hans-Hermann Klünemann
Affiliations

ApoE genotype and family history in patients with dementia and cognitively intact spousal controls

Maria Zintl et al. Am J Alzheimers Dis Other Demen. 2009 Aug-Sep.

Abstract

Objective: To test that a positive family history and ApoE e4 genotype are prevalent among dementia patients with onset before 70 years of age compared with healthy spousal controls.

Methods: A total of 210 patients with dementia and 82 spousal control participants. Neuropsychiatric examination, Consortium to establish a registry on Alzheimer's disease test battery, Clock-drawing Test, and ApoE genotyping were performed in patients and controls.

Results: Of the 131 patients with Alzheimer dementia, 25 were homozygous for Apo e4. Among dementia patients with a positive family history (n = 83), homozygosity for the Apo e4 genotype was found in 19 (22.9%). A positive family history was highest among Apo e4 homozygous Alzheimer dementia patients (72.0%) and lowest among the cognitively normal spousal controls (9.3%).

Conclusions: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history.

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References

    1. Myers RH, Schaefer EJ, Wilson PW, et al. Apolipoprotein E epsilon 4 associated with dementia in a population-based study: The Framingham study. Neurology. 1996. ;46:673-677. - PubMed
    1. Rippon GA, Tang MX, Lee JH, Lantigua R., Medrano M., Mayeux R. Familial Alzheimer disease in Latinos: interaction between APOE, stroke and estrogen replacement. Neurology. 2006;66:35-40. - PMC - PubMed
    1. Olarte L., Schupf N., Lee JH, et al. Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics. Arch Neurology. 2006;63:1586-1590. - PubMed
    1. Mayeux R., Stern Y., Ottman R., et al. The apolipoprotein epsilon 4 allele in patient’s with Alzheimer’s disease. Ann Neurol. 1993. ;34:752-754. - PubMed
    1. Huang W., Qiu C., von Strauss E., Winblad B., Fratiglione L. APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study. Arch Neurol. 2004;61:1930-1934. - PubMed