Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2009 May;108(5):1627-30.
doi: 10.1213/ane.0b013e318199dc72.

Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease

Dmitri Baranov  1 , Philip E Bickler, Gregory J Crosby, Deborah J Culley, Maryellen F Eckenhoff, Roderic G Eckenhoff, Kirk J Hogan, Vesna Jevtovic-Todorovic, András Palotás, Misha Perouansky, Emmanuel Planel, Jeffrey H Silverstein, Huafeng Wei, Robert A Whittington, Zhongcong Xie, Zhiyi Zuo; First International Workshop on Anesthetics and Alzheimer's Disease
Affiliations
Practice Guideline

Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease

Dmitri Baranov et al. Anesth Analg. 2009 May.

Abstract

In order to review the current status of the potential relationship between anesthesia and Alzheimer's disease, a group of scientists recently met in Philadelphia for a full day of presentations and discussions. This special article represents a consensus view on the possible link between Alzheimer's disease and anesthesia and the steps required to test this more definitively.

PubMed Disclaimer

References

    1. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg. 2003;96:1004–9. - PubMed
    1. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology. 2004;100:309–14. - PubMed
    1. Bianchi SL, Tran T, Liu C, Lin S, Li Y, Keller JM, Eckenhoff RG, Eckenhoff MF. Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging. 2007;29:1002–10. - PMC - PubMed
    1. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008;28:4551–60. - PMC - PubMed
    1. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006;104:988–94. - PubMed

Publication types