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. 2009 May;50(5):814-7.
doi: 10.2967/jnumed.108.058131. Epub 2009 Apr 16.

Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET

Charles M Laymon  1 , N Scott Mason, W Gordon Frankle, Jonathan P Carney, Brian J Lopresti, Maralee Y Litschge, Chester A Mathis, James M Mountz, Rajesh Narendran
Affiliations

Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET

Charles M Laymon et al. J Nucl Med. 2009 May.

Abstract

We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses.

Methods: Six subjects (3 women, 3 men) were injected with (11)C-NPA (nominal dose, 370 MBq). A total of 9 consecutive whole-body PET scans were obtained for each subject. In addition, time-activity curves for 12 organs were determined, and residence times were computed for each subject. Dosimetry was determined for the various body organs and the whole body.

Results: The average NPA whole-body radiation dose was 3.17 x 10(-3) mSv per MBq of injected (11)C-NPA. The organ receiving the highest dose was the gallbladder wall, with an average of 2.81 x 10(-2) mSv.MBq(-1).

Conclusion: On the basis of averaged dosimetry results, an administration of less than 1,780 MBq (<48 mCi) of (11)C-NPA yields an organ dose of under 50 mSv (5 rem) to all organs.

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Figures

FIGURE 1
FIGURE 1
11C-NPA coronal PET image (hot metal scale) overlaid on attenuation image reconstructed from transmission data (gray scale) for male subject. PET data have been summed over first 4 scans and the image roughly represents activity distribution averaged over first 20 min after injection.
FIGURE 2
FIGURE 2
Activity concentration, normalized by injected dose, in various organs as function of time.
See this image and copyright information in PMC

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