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Case Reports
. 2009 Sep;24(9):1761-3.
doi: 10.1007/s00467-009-1187-9. Epub 2009 Apr 17.

Nephrogenic diabetes insipidus: treat with caution

Thierry Boussemart  1 , Jacqueline Nsota, Dominique Martin-Coignard, Gérard Champion
Affiliations
Case Reports

Nephrogenic diabetes insipidus: treat with caution

Thierry Boussemart et al. Pediatr Nephrol. 2009 Sep.

Abstract

Current therapy for congenital nephrogenic diabetes insipidus consists of appropriate water intake coupled with decreased urine output obtained by means of a low-sodium diet and a combination of thiazide diuretics with renal prostaglandins inhibitors or amiloride. We report a case of congenital nephrogenic diabetes insipidus that was complicated by paradoxical water intoxication secondary to liberal water intake and the initiation of hydrochlorothiazide and indomethacin combination therapy. This report emphasizes the importance of evaluating the water balance and of a quick response with strict protocols following the initiation of indomethacin and thiazide diuretics in nephrogenic diabetes insipidus.

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