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Clinical Trial
. 2009 Jan;27(1):20-4.
doi: 10.1007/s11604-008-0288-x. Epub 2009 Feb 8.

Influence of hilar deposition in the evaluation of the alveolar epithelial permeability on 99mTc-DTPA aerosol inhaled scintigraphy

Shigeyuki Ogi  1 , Eisuke Gotoh, Mayuki Uchiyama, Kunihiko Fukuda, Mitsuyoshi Urashima, Nobuyoshi Fukumitsu
Affiliations
Clinical Trial

Influence of hilar deposition in the evaluation of the alveolar epithelial permeability on 99mTc-DTPA aerosol inhaled scintigraphy

Shigeyuki Ogi et al. Jpn J Radiol. 2009 Jan.

Abstract

Purpose: We investigated whether hilar radioaerosol deposition affects the clearance rate of technetium-99m-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) from peripheral alveolar regions.

Materials and methods: A total of 38 patients underwent (99m)Tc-DTPA inhalation lung scintigraphy. Six region of interest (ROI) patterns were adopted: ROI 1 was outlined around the entire hemithorax, and ROIs 2-6 were outlined around the hemithorax but excluded square ROIs of different size in the hilar region. Half-times (T(1/2) were calculated with time-activity curves using one-compartment and two-compartment analyses. The T(1/2) of ROIs 1-5 were plotted against the T(1/2) of ROI 6, and regression lines were obtained with the least-squares method. The absolute values of the differences between surveyed values and regression line were calculated. The Wilcoxon test for trend and a single linear regression model were used to determine statistical significance.

Results: There were significant reductions in the absolute values of the differences between surveyed values and regression line from ROIs 1-5 by one-component analysis and the fast component of two-compartment analysis (P < 0.001).

Conclusion: Our results suggest that the deposition of radioaerosol in the hilar region affects the clearance rate of (99m)Tc-DTPA from the alveoli in damaged lungs. The hilar region should be excluded from ROIs when alveolar epithelial permeability is evaluated.

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