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. 2008;8(5-6):461-9.

Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase

Andrea Brancale  1 , Chrisanthy Vlachaki, Dimitrios Vlachakis
Affiliations
  • PMID: 19374131

Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase

Andrea Brancale et al. In Silico Biol. 2008.

Abstract

Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.

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