Comment
doi: 10.1016/j.neuron.2009.04.005.
A p75(NTR) pivoting paradigm propels perspicacity
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- PMID: 19376060
- DOI: 10.1016/j.neuron.2009.04.005
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Comment
A p75(NTR) pivoting paradigm propels perspicacity
Neuron.
.
Free article
Abstract
The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events.
Comment on
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Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers.Neuron. 2009 Apr 16;62(1):72-83. doi: 10.1016/j.neuron.2009.02.020. Neuron. 2009. PMID: 19376068 Free PMC article.
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