Review
doi: 10.1016/j.trim.2009.03.008.
Epub 2009 Apr 17.
Antibody-mediated xenograft injury: mechanisms and protective strategies
Affiliations
- PMID: 19376229
- PMCID: PMC2695451
- DOI: 10.1016/j.trim.2009.03.008
Item in Clipboard
Review
Antibody-mediated xenograft injury: mechanisms and protective strategies
Transpl Immunol.
2009 Jun.
Abstract
The use of porcine organs for clinical transplantation is a promising potential solution to the shortage of human organs. Preformed anti-pig antibody is the primary cause of hyperacute rejection, while elicited antibody can contribute to subsequent "delayed" xenograft rejection. This article will review recent progress to overcome antibody mediated xenograft rejection, through modification of the host immunity and use of genetically engineered pig organs.
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