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. 2009 Jun;94(6):865-9.
doi: 10.3324/haematol.2008.004234. Epub 2009 Apr 18.

Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study

François Girodon  1 , Gilles Bonicelli, Céline Schaeffer, Morgane Mounier, Serge Carillo, Ingrid Lafon, Paule Marie Carli, Inès Janoray, Emmanuelle Ferrant, Marc Maynadié
Affiliations

Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study

François Girodon et al. Haematologica. 2009 Jun.

Abstract

To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Côte d'Or area, France, from 1980 to 2007. A total of 524 myeloproliferative neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 idiopathic myelofibroses. No change in the incidence of either polycythemia vera or idiopathic myelofibrosis was observed for the 2005-2007 period, compared to 1980-2004. On the contrary, a pronounced increase in the incidence of essential thrombocythemia was noted after 2005, mainly due to the use of JAK2 mutation screening and a lower threshold of platelet count. Our study confirms the relevance of the new WHO diagnostic criteria in allowing earlier diagnosis of essential thrombocythemia.

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Figures

Figure 1.
Figure 1.
Evolution of incidence of myeloproliferative neoplasms (MPN), incidence rates from 1980 to 2007 in the Côte d’Or area registry. There was a significant increase in the incidence of essential thrombocytemia (p<0.001) in 2005–2007 compared to 1980–2004 when diagnosed according to the WHO 2008 criteria. Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF).
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