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. 1991 Nov;59(11):4259-62.
doi: 10.1128/iai.59.11.4259-4262.1991.

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S

J Coburn  1 , D M Gill
Affiliations

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S

J Coburn et al. Infect Immun. 1991 Nov.

Abstract

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates p21ras and several related proteins. ADP-ribosylation of p21ras does not alter interactions with guanine nucleotides. The ras-related GTP-binding proteins, including Rab3, Rab4, Ral, Rap1A, and Rap2, are also substrates; given these results, we propose a model for the role of exoenzyme S in pathogenesis.

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