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Review
. 2009 Jun;4(6):905-16.
doi: 10.1002/cmdc.200800436.

Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry

Enrica Calleri  1 , Caterina Temporini, Gabriele Caccialanza, Gabriella Massolini
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Review

Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry

Enrica Calleri et al. ChemMedChem. 2009 Jun.

Abstract

Frontal affinity chromatography coupled to mass spectrometry (FAC-MS) has been reported as a potential method for screening compound mixtures against immobilized target proteins. The potentiality of this analytical approach is described and illustrated with a number of examples based on targets of pharmaceutical interest.

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