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Review
. 2009 Apr;17(2):509-12.

[Progress of study on relationship between Mcl-1 gene and hematologic malignancies - review]

[Article in Chinese]
Zhi-Hui Li  1 , Hui-Min Li
Affiliations
  • PMID: 19379600
Review

[Progress of study on relationship between Mcl-1 gene and hematologic malignancies - review]

[Article in Chinese]
Zhi-Hui Li et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr.

Abstract

Mcl-1 (myeloid cell leukemia-1) is a member of Bcl-2 (B cell leukemia-2) family, which may play an important role in cell apoptosis regulation, occurrence and development of tumors. This paper reviews advance of studies on the function of the mcl-1 gene and MCL-1 protein, the signal transduction pathways (JAK/STAT, MAPK, PI-3K) regulating the expression of mcl-1 gene, and the relationship between mcl-1 gene and hematologic malignancies.

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