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Case Reports
. 2009 Jun;32(6):E94-6.
doi: 10.1002/clc.20291.

Paclitaxel-induced ST-segment elevations

Gökmen Gemici  1 , Altuğ Cinçin, Muzaffer Değertekin, Ahmet Oktay
Affiliations
Case Reports

Paclitaxel-induced ST-segment elevations

Gökmen Gemici et al. Clin Cardiol. 2009 Jun.

Abstract

A 51-year-old woman presented with severe chest pain minutes after starting intravenous paclitaxel as a part of the systemic chemotherapy due to ovarian carcinoma. The electrocardiogram (ECG) revealed sinus rhythm with ST-segment elevations in inferior and anterior leads. The ST-segment elevations resolved immediately after sublingual nitroglycerine. Cardiac troponin T and CPK MB levels remained in the normal range at repeat measurements. It was presumed that in spite of standard premedication, paclitaxel had induced acute coronary syndrome with ST-segment elevations in this patient.

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References

    1. Markman M. New, expanded, and modified use of approved antineoplastic agents in ovarian cancer. Oncologist. 2007; 12: 186–190. - PubMed
    1. Markman M, Kennedy A, Webster K, Kulp B, Peterson G, et al. Paclitaxel‐associated hypersensitivity reactions: experience of the gynecologic oncology program of the Cleveland Clinic Cancer Center. J Clin Oncol. 2000; 18: 102–105. - PubMed
    1. Sendo T, Sakai N, Itoh Y, Ikesue H, Kobayashi H, et al. Incidence and risk factors for paclitaxel hypersensitivity during ovarian cancer chemotherapy. Cancer Chemother Pharmacol. 2005; 56: 91–96. - PubMed
    1. Nguyen‐Ho P, Kleiman NS, Verani MS. Acute myocardial infarction and cardiac arrest in a patient receiving paclitaxel. Can J Cardiol. 2003; 19: 300–302. - PubMed
    1. Schrader C, Keussen C, Bewig B, von Freier A, Lins M. Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel (Taxol) in a patient with meta‐ static ovarian carcinoma. Eur J Med Res. 2005; 10: 498–501. - PubMed

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