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. 2007 Dec;1(3):350-5.
doi: 10.1016/j.molonc.2007.08.005. Epub 2007 Sep 1.

Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7

David Lindquist  1 , Mircea Romanitan, Lalle Hammarstedt, Anders Näsman, Hanna Dahlstrand, Johan Lindholm, Liselotte Onelöv, Torbjörn Ramqvist, Weimin Ye, Eva Munck-Wikland, Tina Dalianis
Affiliations

Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7

David Lindquist et al. Mol Oncol. 2007 Dec.

Abstract

From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer.

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Figures

Figure 1
Figure 1
Patients with HPV‐positive tumours had a better disease‐specific survival than patients with HPV‐negative tumours, independent of age, gender and tumour stage.
See this image and copyright information in PMC

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