Innovations, challenges and future prospects of oncoproteomics

Abstract

Oncoproteomics is playing an increasingly important role in the diagnosis and management of cancer as well as in the development of personalized treatment of cancer. Innovative proteomic technologies relevant to cancer are described briefly, which are helping in the understanding of mechanism of drug resistance in cancer and will provide some leads to improve the management. Most important of these are nanoproteomics, i.e. application of nanobiotechnology to proteomics is playing an important role in nanooncology. Examples of some cancers will be given to point out the challenges and future prospects of oncoproteomics including those involving translation of technologies from the bench to the bedside.

Figure 1

This figure shows the interrelationships of oncoproteomics with other technologies used. Oncogenomics plays an important role by diagnostics as well as drug discovery, as both are components of personalized medicine. Technologies such as nanobiotechnology can also enhance both diagnostics and drug development for cancer.