Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Apr 21;2(67):pe24.
doi: 10.1126/scisignal.267pe24.

The pharmacology of mTOR inhibition

David A Guertin  1 , David M Sabatini
Affiliations

The pharmacology of mTOR inhibition

David A Guertin et al. Sci Signal. .

Abstract

A flurry of reports indicates that we are entering a new phase in the development of mammalian target of rapamycin (mTOR)-based therapies for oncology. Here, we summarize exciting findings regarding mTOR signaling and the outlook for mTOR inhibitors as tools to study the mTOR pathway and as drugs in the clinic.

PubMed Disclaimer

MeSH terms

LinkOut - more resources