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. 2009 Apr 7;14(4):1456-67.
doi: 10.3390/molecules14041456.

Polyphenolic profile and bioactivity study of Oenothera speciosa Nutt. aerial parts

Mohamed S Marzouk  1 , Fatma A Moharram, Rabab A El Dib, Siham M El-Shenawy, Ahmed F Tawfike
Affiliations

Polyphenolic profile and bioactivity study of Oenothera speciosa Nutt. aerial parts

Mohamed S Marzouk et al. Molecules. .

Abstract

Two new flavonol glycosides, myricetin 4'-O-alpha-L-rhamnopyranoside (1) and quercetin 3'-O-alpha-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-alpha-L-(1)C(4)-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-beta-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg(-1)b wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin(4) and hyperin(7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.

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Figures

Figure 1
Figure 1
Structures of compounds 1, 2 and 3.
Figure 2
Figure 2
Antioxidant activity in vitro using the DPPH radical scavenging activity method. (a) Antioxidant activity of 80 % aqueous methanol extract of O. speciosa and ascorbic acid. (b) Antioxidant activity of myricitrin and ascorbic acid. (c) Antioxidant activity of hyperin and ascorbic acid.
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References

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