Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991;96(1):65-72.
doi: 10.1007/BF00266763.

Expression of epidermal growth factor in the rat kidney. An immunocytochemical and in situ hybridization study

E C Salido  1 , J Lakshmanan, D A Fisher, L J Shapiro, L Barajas
Affiliations

Expression of epidermal growth factor in the rat kidney. An immunocytochemical and in situ hybridization study

E C Salido et al. Histochemistry. 1991.

Abstract

The renal localization and the site of synthesis of epidermal growth factor (EGF) were investigated in the rat kidney by immunohistochemistry and in situ hybridization techniques. EGF was localized in the cells of the thick ascending limb of Henle (TAL) and distal convoluted tubule (DCT). At the ultrastructural level, EGF immunoreactivity was distributed on the apical membrane and trans-Golgi complex of the TAL and DCT cells. These segments of the rat nephron also hybridized to prepro-EGF cRNA probes in a specific manner, indicating that TAL and DCT are the sites of EGF synthesis in the rat kidney.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Physiol. 1989 Apr;256(4 Pt 2):F632-8 - PubMed
    1. Am J Physiol. 1989 May;256(5 Pt 2):F803-9 - PubMed
    1. Kidney Int. 1989 Nov;36(5):810-5 - PubMed
    1. J Biol Chem. 1990 Mar 25;265(9):4934-8 - PubMed
    1. J Clin Invest. 1988 Sep;82(3):1028-39 - PubMed

Publication types

LinkOut - more resources