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. 2009 Jul;46(4):904-11.
doi: 10.1111/j.1469-8986.2009.00811.x. Epub 2009 Apr 6.

The impact of menstrual cycle phase on cardiac autonomic regulation

Paula S McKinley  1 , Arlene R King, Peter A Shapiro, Iordan Slavov, Yixin Fang, Ivy S Chen, Larry D Jamner, Richard P Sloan
Affiliations

The impact of menstrual cycle phase on cardiac autonomic regulation

Paula S McKinley et al. Psychophysiology. 2009 Jul.

Abstract

This study investigated menstrual cycle phase differences in heart rate (HR) and RR interval variability (RRV) in 49 healthy, premenopausal, eumenorrheic women (age 30.2+/-6.2 years). HR and RRV were computed from ambulatory 24-h electrocardiogram, collected for up to 6 days, with at least 1 day each during early to midfollicular and midluteal menstrual phases. Phase effects on HR and RRV were assessed using linear mixed effects models with a random intercept to account for the correlation of observations within each subject as well as intrasubject variation. During follicular phase monitoring, women had significantly lower average HR (-2.33 bpm), and higher standard deviation, the root mean squared successive difference, and high frequency (0.04-0.15 Hz) and low frequency (0.15-0.40 Hz) RRV than during the luteal phase. These results provide strong support for the influence of menstrual phase on cardiac autonomic regulation in premenopausal women.

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Figures

Figure. 1
Figure. 1
Study protocol: Menstrual phase tracking and timing of ECG monitoring.
Figure. 2
Figure. 2
Menstrual phase differences in HR and RRV outcomes. HR=heart rate; ln=natural logarithim; SDRR=standard deviation of RR interval series; LF=low frequency (0.04–0.15 Hz); HF=high frequency (0.15–0.50 Hz); RRV=RR interval variability. *p<.05, **p<.01.
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