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Case Reports
. 2009 Jun;47(6):1961-4.
doi: 10.1128/JCM.00196-09. Epub 2009 Apr 22.

Outbreak of nontuberculous mycobacterial subcutaneous infections related to multiple mesotherapy injections

Anne Carbonne  1 , Florence Brossier, Isabelle Arnaud, Iheb Bougmiza, Eric Caumes, Jean-Paul Meningaud, Sylvie Dubrou, Vincent Jarlier, Emmanuelle Cambau, Pascal Astagneau
Affiliations
Case Reports

Outbreak of nontuberculous mycobacterial subcutaneous infections related to multiple mesotherapy injections

Anne Carbonne et al. J Clin Microbiol. 2009 Jun.

Abstract

We describe an outbreak of severe subcutaneous infections due to nontuberculous mycobacteria following mesotherapy. Epidemiological studies and molecular comparisons of Mycobacterium chelonae strains from different patients and the environment suggested that contamination may be associated with inappropriate cleaning of the multiple-injection device with tap water.

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Figures

FIG. 1.
FIG. 1.
Picture of multiple subcutaneous abscesses due to M. chelonae after injections for mesotherapy.
FIG. 2.
FIG. 2.
(A) Dendrogram based on the PFGE patterns of 20 M. chelonae isolates (11 from mesotherapy patients, 1 from tap water in the medical examination room, and 9 control strains), prepared using the Dice-unweighted-pair group method with arithmetic means. The letters of the corresponding lanes in panel B are indicated to the right. (B) PFGE patterns of M. chelonae genomic DNA digested with XbaI. Lanes: A, M. chelonae control strain 4; B to L, M. chelonae isolates from mesotherapy patients; M, M. chelonae isolate from tap water in the medical examination room; N, lambda ladder gel marker. Molecular sizes (in kilobases) of the DNA standards are given to the right of the gel.
See this image and copyright information in PMC

References

    1. Astagneau, P., N. Desplaces, V. Vincent, V. Chicheportiche, A. Botherel, S. Maugat, K. Lebascle, P. Leonard, J. Desenclos, J. Grosset, J. Ziza, and G. Brucker. 2001. Mycobacterium xenopi spinal infections after discovertebral surgery: investigation and screening of a large outbreak. Lancet 358747-751. - PubMed
    1. Centers for Disease Control and Prevention. 2005. Outbreak of mesotherapy-associated skin reactions—District of Columbia area, January-February 2005. MMWR Morb. Mortal. Wkly. Rep. 541127-1130. - PubMed
    1. De Groote, M. A., and G. Huitt. 2006. Infections due to rapidly growing mycobacteria. Clin. Infect. Dis. 421756-1763. - PubMed
    1. Furuya, E. Y., A. Paez, A. Srinivasan, R. Cooksey, M. Augenbraun, M. Baron, K. Brudney, P. la-Latta, C. Estivariz, S. Fischer, M. Flood, P. Kellner, C. Roman, M. Yakrus, D. Weiss, and E. V. Granowitz. 2008. Outbreak of Mycobacterium abscessus wound infections among “lipotourists” from the United States who underwent abdominoplasty in the Dominican Republic. Clin. Infect. Dis. 461181-1188. - PubMed
    1. Le Dantec, C., J. P. Duguet, A. Montiel, N. Dumoutier, S. Dubrou, and V. Vincent. 2002. Occurrence of mycobacteria in water treatment lines and in water distribution systems. Appl. Environ. Microbiol. 685318-5325. - PMC - PubMed

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