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. 2009 Apr 21;70(5):732-40.
doi: 10.4088/JCP.08m04821.

The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis

Joseph Biederman  1 , Carter R Petty, Michael C Monuteaux, Margaret Evans, Tiffany Parcell, Stephen V Faraone, Janet Wozniak
Affiliations

The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis

Joseph Biederman et al. J Clin Psychiatry. .

Abstract

Objective: To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder.

Method: Subjects were ascertained from 2 identically designed longitudinal case-control family studies of subjects (males and females aged 6-18 years) with DSM-III-R attention-deficit/hyperactivity disorder (ADHD). Based on data from the baseline assessment, ADHD subjects without a lifetime diagnosis of bipolar disorder were stratified by the presence (CBCL-PBD positive, N=28) or absence (CBCL-PBD negative, N=176) of a CBCL-PBD score > or = 210 (total of attention, aggression, and anxious/depressed subscales). Subjects were comprehensively assessed at follow-up with structured psychiatric interviews. Data were collected from April 1988 to February 2003.

Results: Over a mean follow-up period of 7.4 years, a positive CBCL-PBD score predicted subsequent diagnoses of bipolar disorder, major depressive disorder, and conduct disorder, as well as impaired psychosocial functioning and higher risk for psychiatric hospitalization.

Conclusion: This work suggests that a positive CBCL-PBD score based on elevations on the attention problems, aggressive behavior, and anxious/depressed subscales predicts subsequent pediatric bipolar disorder and associated syndrome-congruent impairments. If confirmed in other studies, the CBCL-PBD score has the potential to help identify children at high risk to develop bipolar disorder.

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Figures

Figure 1
Figure 1
Risk for mood and conduct disorders by CBCL-PBD score.
Figure 2
Figure 2
Risk for psychopathology by CBCL-PBD score.
Figure 3
Figure 3
Psychosocial functioning over time by CBCL-PBD score
Figure 4
Figure 4
Risk for Hospitalization
See this image and copyright information in PMC

References

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