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. 2009 Mar;114(2):100-9.
doi: 10.1352/2009.114.100-109.

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

Laura Guazzarotti  1 , Daria Trabattoni, Eleonora Castelletti, Benedetta Boldrighini, Luca Piacentini, Piergiorgio Duca, Silvia Beretta, Michela Pacei, Cristiana Caprio, Alessandra Vigan Ago, Berardo di Natale, Gian Vincenzo Zuccotti, Mario Clerici
Affiliations

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)

Laura Guazzarotti et al. Am J Intellect Dev Disabil. 2009 Mar.

Abstract

Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

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