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. 2009 Jun;200(6):678.e1-6.
doi: 10.1016/j.ajog.2009.02.032. Epub 2009 Apr 23.

Incidence of endometrial hyperplasia

Susan D Reed  1 , Katherine M Newton, Walter L Clinton, Meira Epplein, Rochelle Garcia, Kimberly Allison, Lynda F Voigt, Noel S Weiss
Affiliations

Incidence of endometrial hyperplasia

Susan D Reed et al. Am J Obstet Gynecol. 2009 Jun.

Abstract

Objective: The objective of the study was to estimate the age-specific incidence of endometrial hyperplasia: simple, complex, and atypical, in order of increasing likelihood of progression to carcinoma.

Study design: Women aged 18-90 years with endometrial pathology specimens (1985-2003) at a large integrated health plan were identified using automated data. Incidence rates were obtained by dividing the number of cases by the estimated number of female health plan enrollees who retained a uterus.

Results: Endometrial hyperplasia peak incidence was: simple, 142 per 100,000 woman-years, complex, 213 per 100,000 woman-years, both in the early 50s; and atypical, 56 per 100,000 woman-years in the early 60s. Age-adjusted incidence decreased over the study period, especially for atypical hyperplasia.

Conclusion: Endometrial hyperplasia incidence without and with atypia peaks in the early postmenopausal years and in the early 60s, respectively. Given that some cases of endometrial hyperplasia likely go undiagnosed, the figures provided should be viewed as minimum estimates of the true incidence.

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Figures

Figure 1
Figure 1
Endometrial Specimens from 1985–2003, Group Health, Seattle, Washington.
Figure 2
Figure 2
Temporal Trends from 1985–2003 of Incidence of Simple, Complex and Atypical Endometrial Hyperplasia, Group Health, Seattle, Washington. The x-axis shows time from 1985–2003 for the 3 different types of endometrial hyperplasia (simple, complex and atypia). The y-axis defines incidence per 100,000 women years.
See this image and copyright information in PMC

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