Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jul;16(7):798-809.
doi: 10.1016/j.acra.2008.12.025. Epub 2009 Apr 25.

Improved detection of hepatic metastases with contrast-enhanced low mechanical-index pulse inversion ultrasonography during the liver-specific phase of sonazoid: observer performance study with JAFROC analysis

Katsutoshi Sugimoto  1 , Junji Shiraishi, Fuminori Moriyasu, Kazuhiro Saito, Kunio Doi
Affiliations

Improved detection of hepatic metastases with contrast-enhanced low mechanical-index pulse inversion ultrasonography during the liver-specific phase of sonazoid: observer performance study with JAFROC analysis

Katsutoshi Sugimoto et al. Acad Radiol. 2009 Jul.

Abstract

Rationale and objectives: To compare B-mode ultrasonography (US) alone with the combination of B-mode and contrast-enhanced (Sonazoid) late-phase pulse-inversion US for the detection of hepatic metastases by use of jackknife free-response receiver-operating characteristic (JAFROC) analysis.

Materials and methods: Twenty-seven patients with 57 hepatic metastases and 6 patients without hepatic metastases underwent B-mode and contrast-enhanced US. We used the diagnoses established by contrast-enhanced computed tomography and contrast-enhanced US as the standard of reference. All ultrasonographic scanning was performed by an experienced radiologist with a routine clinical procedure. All scanning data were archived with digital cine clips. A review system, which can display pairs of cine clips for B-mode and contrast-enhanced US side by side, was developed for off-site observer study. Seven radiologists interpreted each case individually first by B-mode US only, and then by the combination with contrast-enhanced US by identifying locations of possible candidates for hepatic metastasis with their confidence ratings. The figure-of-merit (FOM) values, sensitivity, and false-positives per case were estimated for B-mode US alone, and for the combination of B-mode and contrast-enhanced US.

Results: The sensitivities of the combined ultrasonographic imaging (mean, 72.2%) were clearly improved from that of B-mode US alone (mean, 41.6%) while reducing the average number of false positives from 1.1 to 0.5 per case. In the jackknife analysis, there was a statistically significant difference between mean FOM values for the combined imaging (0.76) and for B-mode US alone (0.44, P < .00001).

Conclusion: Evaluating cine clips of contrast-enhanced liver US together with B-mode US could improve physicians' accuracy for detection of hepatic metastases.

PubMed Disclaimer

Publication types

LinkOut - more resources