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. 2009;44(7):726-32.
doi: 10.1007/s00535-009-0049-3. Epub 2009 Apr 25.

Long-term outcome of autoimmune pancreatitis

Kazushige Uchida  1 , Shujiro Yazumi, Akiyoshi Nishio, Takeo Kusuda, Masaki Koyabu, Masanori Fukata, Hideaki Miyoshi, Yutaku Sakaguchi, Toshiro Fukui, Mitsunobu Matsushita, Makoto Takaoka, Kazuichi Okazaki
Affiliations

Long-term outcome of autoimmune pancreatitis

Kazushige Uchida et al. J Gastroenterol. 2009.

Abstract

Purpose: Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP.

Methods: For this study, we recruited 21 patients, averaging 66.5 years in age (range, 19-84 years) and observed them at a mean interval of 40.8 months (range, 18-130 months). Three of the patients were also diagnosed with retroperitoneal fibrosis, 3 had sialoadenitis, 2 had chronic thyroiditis, 1 had interstitial nephritis, and 1 had interstitial pneumonia. Three of the patients underwent surgical therapy, 12 patients received methylprednisolone (PSL) treatment, and the 6 remaining patients received no treatment.

Results: Enlargement of the pancreas was attenuated in all the PSL-treated patients. Seven of the 21 patients showed pancreatic atrophy, of whom 2 were non-PSL-treated patients. Three patients developed chronic pancreatitis. One patient was diagnosed with pancreatic cancer after 50 months of PSL therapy.

Conclusions: As with chronic pancreatitis patients, AIP patients should be observed closely for abnormality in pancreatic function.

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