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Review
. 2009 Jun;16(3):246-53.
doi: 10.1097/med.0b013e32832b100a.

Androgens and hair loss

Adel Alsantali  1 , Jerry Shapiro
Affiliations
Review

Androgens and hair loss

Adel Alsantali et al. Curr Opin Endocrinol Diabetes Obes. 2009 Jun.

Abstract

Purpose of review: Androgenetic alopecia (AGA) or male pattern hair loss is a very common condition that has a significant psychosocial impact for patients. Many advances in the pathogenesis and treatment of AGA have been discovered recently. We discuss the pathogenesis and treatment of AGA.

Recent findings: Wide genome analysis showed an association of AGA and chromosome 20pll in addition to androgen-receptor gene. Also, a locus on chromosome 3q26 was found to have a linkage with AGA. Dutasteride has been shown to be more effective than finasteride in the treatment of AGA but is not yet a recommended therapy. In an in-vitro study, a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution.

Summary: These recent developments in the field of AGA hold some promise and may play a role in the future management.

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