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Review
. 2009 Apr 28;119(16):2217-24.
doi: 10.1161/CIRCULATIONAHA.107.715839.

MicroRNAs: regulating a change of heart

Kurt G Barringhaus  1 , Phillip D Zamore
Affiliations
Review

MicroRNAs: regulating a change of heart

Kurt G Barringhaus et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
miRNA biosynthesis pathway. Following cleavage of the pri-miRNA by Drosha, pre-miRNA exits the nucleus and is cleaved by Dicer to a duplex. From this miRNA/miRNA* duplex, the miRNA strand is loaded into the RNA-induced silencing complex (RISC), and the miRNA* strand is destroyed. Translational repression of targeted mRNAs by RISC may occurs within the P-Body.
Figure 2
Figure 2
miR-1 and miR-133 regulate progenitor cell self-renewal and cardiomyocyte differentiation from embryonic stem (ES) cells.
Figure 3
Figure 3
miRNAs regulate cardiac development and the stress response in mice. A, miR-208 deletion abrogates left ventricular hypertrophy induced by thoracic aortic banding. B, Transepicardial injection of a miR-133 inhibitor induces LVH in mice. C, miR-1 and miR-195 over expression produces a phenotype exhibiting thinned and dilated ventricles. D, miR-1−2 deficient mice have ventricular septal defects. E, Transepicardial injection of a 2′-O-methyl antisense oligonucleotide targeting miR-1 prior to coronary artery ligation reduces post-infarction dysrhythmias.
See this image and copyright information in PMC

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