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Randomized Controlled Trial
. 2009 Apr;17(1):1-5.
doi: 10.1177/230949900901700101.

Thromboembolic prophylaxis for total knee arthroplasty in Asian patients: a randomised controlled trial

P L Chin  1 , M S Amin, K Y Yang, S J Yeo, N N Lo
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Free article
Randomized Controlled Trial

Thromboembolic prophylaxis for total knee arthroplasty in Asian patients: a randomised controlled trial

P L Chin et al. J Orthop Surg (Hong Kong). 2009 Apr.
Free article

Abstract

Purpose: To compare the efficacy and safety of different modes of thromboembolic prophylaxis for elective total knee arthroplasty (TKA) in Asian patients.

Methods: 440 low-risk patients undergoing TKA were randomised into 4 equal groups: (1) no prophylaxis (control), (2) graduated compression stockings (GCS), (3) intermittent pneumatic compression (IPC), and (4) low-molecular-weight heparin (enoxaparin). Duplex ultrasonography was used as an assessment tool.

Results: The deep vein thrombosis point prevalence was highest in the control group (22%), which was significantly higher than in patients receiving IPC (8%, p=0.032) or enoxaparin (6%, p=0.001). One patient each in the control and GCS groups developed a non-fatal pulmonary embolism. Patients on enoxaparin received more blood transfusions and 2 of them had major bleeding complications.

Conclusion: IPC is the preferred method of thromboprophylaxis for TKA in Asian patients.

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