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. 2009 Apr;24(2):269-74.
doi: 10.3346/jkms.2009.24.2.269. Epub 2009 Apr 20.

Clinical features and outcomes of microscopic polyangiitis in Korea

Ji Seon Oh  1 , Chang-Keun Lee, Yong Gil Kim, Seong-Su Nah, Hee-Bom Moon, Bin Yoo
Affiliations

Clinical features and outcomes of microscopic polyangiitis in Korea

Ji Seon Oh et al. J Korean Med Sci. 2009 Apr.

Abstract

Microscopic polyangiitis (MPA) is a systemic vasculitis affecting small vessels. To determine the clinical features and outcomes of MPA in Korean patients, we retrospectively reviewed the medical records of patients diagnosed with MPA at a single medical center in Korea between 1989 and 2006. The 18 patients who met the Chapel Hill criteria for MPA had a mean (+/-SD) age at the time of diagnosis of 62.4+/-12.7 yr. Renal manifestations and general symptoms were the most common features of MPA, with lung involvement also very common. Antineutrophil cytoplasmic antibodies (ANCA) were present in 17 of the 18 patients (94%). Of 17 patients treated with steroids and cyclophosphamide, 11 (65%) had stable or improved course. One patient treated with steroids without cyclophosphamide showed disease progression. Ten of the 18 patients (56%) died at a median follow-up of 8 months. MPA in Korean patients was distinguished by a higher rate of lung involvement, especially alveolar hemorrhage, which was the leading cause of death in our patients. Korean patients were also older at MPA onset and were more likely positive for ANCA. Other overall clinical manifestations did not differ significantly.

Keywords: Antibodies, Antineutrophil Cytoplasmic; Microscopic Polyangiitis; Vasculitis.

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Figures

Fig. 1
Fig. 1
Kaplan-Meier survival curve for the 18 patients with microscopic polyangiitis.
Fig. 2
Fig. 2
Kaplan-Meier survival curves for the 18 patients with microscopic polyangiitis relative to (A) Five-Factor Score (p not significant), (B) Birmingham Vasculitis Activity Score (p=0.1), (C) age (p=0.16), and (D) presence or absence of alveolar hemorrhage (p=0.0016). Data were analyzed using the log-rank test.
See this image and copyright information in PMC

References

    1. Davson J, Ball J, Platt R. The kidney in periarteritis nodosa. Q J Med. 1948;17:175–202. - PubMed
    1. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG, McCluskey RT, Sinico RA, Rees AJ, Van Es LA, Waldherr R, Wiik A. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994;37:187–192. - PubMed
    1. Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, Amouroux J, Casassus P, Jarrousse B. Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. Arthritis Rheum. 1999;42:421–430. - PubMed
    1. Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, Thibult N, Casassus P. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 1996;75:17–28. - PubMed
    1. Luqmani RA, Bacon PA, Moots RJ, Janssen BA, Pall A, Emery P, Savage C, Adu D. Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM. 1994;87:671–678. - PubMed

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