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Randomized Controlled Trial
. 2009 Apr 28;15(16):2005-8.
doi: 10.3748/wjg.15.2005.

Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study

Thawatchai Akaraviputh  1 , Charay Leelouhapong, Varut Lohsiriwat, Somkiat Aroonpruksakul
Affiliations
Randomized Controlled Trial

Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study

Thawatchai Akaraviputh et al. World J Gastroenterol. .

Abstract

Aim: To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy.

Methods: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded.

Results: There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However, there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P = 0.053).

Conclusion: Perioperative administration of parecoxib provided no significant effect on postoperative pain relief after laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.

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Figures

Figure 1
Figure 1
Average visual pain score (0 = no pain, 10 = worst possible pain) at 3, 6, 9, 12, 15, 18, 21 and 24 h after surgery in the treatment group and control group.
See this image and copyright information in PMC

References

    1. Woolf CJ. Generation of acute pain: central mechanisms. Br Med Bull. 1991;47:523–533. - PubMed
    1. Lohsiriwat V, Lert-akyamanee N, Rushatamukayanunt W. Efficacy of pre-incisional bupivacaine infiltration on postoperative pain relief after appendectomy: prospective double-blind randomized trial. World J Surg. 2004;28:947–950. - PubMed
    1. Gottschalk A, Smith DS. New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001;63:1979–1984. - PubMed
    1. Reuben SS. Update on the role of nonsteroidal anti-inflammatory drugs and coxibs in the management of acute pain. Curr Opin Anaesthesiol. 2007;20:440–450. - PubMed
    1. Reuben SS, Buvenandran A, Katz B, Kroin JS. A prospective randomized trial on the role of perioperative celecoxib administration for total knee arthroplasty: improving clinical outcomes. Anesth Analg. 2008;106:1258–1264, table of contents. - PubMed

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