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Case Reports
. 2009 Apr 28:2:19.
doi: 10.1186/1756-8722-2-19.

Treatment of multicentric Castleman's Disease accompanying multiple myeloma with bortezomib: a case report

Zhen-gang Yuan  1 , Xiao-yi Dun, Yong-hua Li, Jian Hou
Affiliations
Case Reports

Treatment of multicentric Castleman's Disease accompanying multiple myeloma with bortezomib: a case report

Zhen-gang Yuan et al. J Hematol Oncol. .

Abstract

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi's sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been well established up to now. We here reported a case of rare MCD complicated with multiple myeloma who received bortezomib and achieved very good remission. To our knowledge, this is the first report on MCD in the setting of multiple myeloma with good response to bortezomib.

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Figures

Figure 1
Figure 1
X-ray revealed low density foci on the skull(posterior-anterior and lateral film).
Figure 2
Figure 2
Pathology of an enlarged cervical lymph node was compatible with Castleman's disease, plasma cell type (H & E stain: 400× and 1000×).
Figure 3
Figure 3
Immunohistochemistry showed Vs38(+) (400× and 1000×).
See this image and copyright information in PMC

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