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. 1977 Jun 1;145(6):1607-11.
doi: 10.1084/jem.145.6.1607.

On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain

J A Cohn, A P Alvares, A Kappas

On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain

J A Cohn et al. J Exp Med. .

Abstract

The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.

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