Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 May;58(5):1035-6.
doi: 10.2337/db09-0215.

GPR40: good cop, bad cop?

Thierry Alquier  1 , Vincent Poitout
Affiliations
Comment

GPR40: good cop, bad cop?

Thierry Alquier et al. Diabetes. 2009 May.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Two alternative hypotheses on the mechanisms behind lipid-induced insulin resistance and β-cell compensation. A: According to Steneberg et al. (9), the GPR40-mediated increase in insulin secretion in response to high-fat diet causes insulin resistance. B: In contrast, previous reports (12,13,15) and the findings of Nagasumi et al. (3) suggest that the lipid-induced GPR40-mediated increase in insulin secretion contributes to β-cell compensation for insulin resistance. FA, fatty acid.
See this image and copyright information in PMC

Comment on

References

    1. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR, Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 2003; 278: 11303– 11311 - PubMed
    1. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003; 422: 173– 176 - PubMed
    1. Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y: Overexpression of GPR40 in pancreatic β-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 2009; 58: 1067– 1076 - PMC - PubMed
    1. Shapiro H, Shachar S, Sekler I, Hershfinkel M, Walker MD: Role of GPR40 in fatty acid action on the beta cell line INS-1E. Biochem Biophys Res Commun 2005; 335: 97– 104 - PubMed
    1. Itoh Y, Hinuma S: GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion. Hepatol Res 2005; 33: 171– 173 - PubMed

Publication types