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. 2009 May;15(5):710-8.
doi: 10.3201/eid1505.081119.

A case-control study on the origin of atypical scrapie in sheep, France

Alexandre Fediaevsky  1 , Eric Morignat, Christian Ducrot, Didier Calavas
Affiliations

A case-control study on the origin of atypical scrapie in sheep, France

Alexandre Fediaevsky et al. Emerg Infect Dis. 2009 May.

Abstract

A matched case-control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. We analyzed contacts with animals from other flocks, lambing and feeding practices, and exposure to toxic substances. Data on the prnp genotype were collected for some case and control animals and included in a complementary analysis. Sheep dairy farms had a higher risk for scrapie (odds ratio [OR] 15.1, 95% confidence interval [CI] 3.3-69.7). Lower risk was associated with organic farms (OR 0.15, 95% CI 0.02-1.26), feeding corn silage (OR 0.16, 95% CI 0.05-0.53), and feeding vitamin and mineral supplements (OR 0.6, 95% CI 0.32-1.14). Genetic effects were quantitatively important but only marginally changed estimates of other variables. We did not find any risk factor associated with an infectious origin of scrapie. Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors.

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Figures

Figure 1
Figure 1
Distribution of cases of atypical scrapie and controls (no. cases/no. controls) in sheep, France, 2007. Sheep production areas are outlined in black, and counties are outlined in gray.
Figure 2
Figure 2
Distribution of C0 for cases of atypical scrapie and controls in sheep, France, 1994–2005. C0, birth cohort assuming that in each flock all animals born during the same birth campaign (defined from July 1 of year n – 1 to June 30 of year n) shared the same exposure.
Figure 3
Figure 3
Distribution of control weightings calculated as the ratio of the percentage of flocks with >20 ewes in the county over the average percentage of flocks with >20 ewes for atypical scrapie in sheep, in France, 2007. Ranges represent classes of weightings.
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