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. 2009 May;15(5):761-5.
doi: 10.3201/eid1505.081154.

Hospitalizations and deaths associated with Clostridium difficile infection, Finland, 1996-2004

Outi Lyytikäinen  1 , Heli Turunen, Reijo Sund, Marja Rasinperä, Eija Könönen, Petri Ruutu, Ilmo Keskimäki
Affiliations

Hospitalizations and deaths associated with Clostridium difficile infection, Finland, 1996-2004

Outi Lyytikäinen et al. Emerg Infect Dis. 2009 May.

Abstract

To determine whether the rate of Clostridium difficile-associated disease (CDAD) and CDAD-related deaths were increasing in Finland, we analyzed registry data from 1996 through 2004. We determined the number of hospital discharges that had a diagnosis code specific for CDAD from the International Classification of Diseases, 10th revision: "enterocolitis due to Clostridium difficile" (A04.7) and "pseudomembranous enterocolitis associated with antimicrobial therapy" (K52.8), listed as any diagnosis in the National Hospital Discharge Registry. CDAD-related deaths were identified from death certificates. Those discharged with a CDAD diagnosis doubled from 810 (16/100,000 population) in 1996 to 1,787 (34/100,000) in 2004. The increase was most prominent for patients 7gt;64 years of age but concerned only those discharged with diagnosis code A04.7. The number of those discharged with diagnosis code K52.8 remained stable. The age-standardized mortality rate associated with CDAD increased from 9/million in 1998 to 17/million in 2004; the increase was limited to persons 7gt;64 years of age.

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Figures

Figure 1
Figure 1
Number of hospital discharges with Clostridium difficile listed as any and primary diagnoses, 1996–2004, Finland. International Classification of Diseases, 10th revision, codes K52.8, “pseudomembranous enterocolitis associated with antimicrobial drug therapy,” and A04.7, “enterocolitis due to Clostridium difficile.”
Figure 2
Figure 2
Rates of hospital discharges with Clostridium difficile listed as any diagnosis, by age, 1996–2004, Finland.
Figure 3
Figure 3
Mortality rates associated with Clostridium difficile, by age, 1996–2004, Finland.
See this image and copyright information in PMC

References

    1. Kuijper EJ, Coignard B, Tull P. ESCMID Study Group for Clostridium difficile, EU Member States, European Centre for Disease Prevention and Control. Emergence of Clostridium difficile–associated disease in North America and Europe. Clin Microbiol Infect. 2006;12(Suppl 6):2–18. 10.1111/j.1469-0691.2006.01580.x - DOI - PubMed
    1. McDonald LC, Killgore GE, Thompson A, Owens RC Jr, Kazakova SV, Sambol SP, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med. 2005;353:2433–41. 10.1056/NEJMoa051590 - DOI - PubMed
    1. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud M, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile–associated diarrhea with high morbidity and mortality. N Engl J Med. 2005;353:2442–9. 10.1056/NEJMoa051639 - DOI - PubMed
    1. Kuijper EJ, Barbut F, Brazier J, Kleinkauf N, Eckmanns T, Lambert ML, et al. Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Euro Surveill 2008;12(31):pii=18942 [cited 2008 Aug 25]. Available from http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18942. - PubMed
    1. Lyytikäinen O, Mentula S, Könönen E, Kotila S, Tarkka E, Anttila V-J, et al. First isolation of Clostridium difficile PCR ribotype 027 in Finland. Euro Surveill 2007;12(45):pii=3303 [cited 2008 Aug 25]. Available from http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=3303. - PubMed

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