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Review
. 2009 Apr 29;29(17):5367-9.
doi: 10.1523/JNEUROSCI.0235-09.2009.

Kalirin-7: linking spine plasticity and behavior

Julia E Sommer  1 , Elaine C Budreck
Affiliations
Review

Kalirin-7: linking spine plasticity and behavior

Julia E Sommer et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Kalirin-7-mediated alterations in dendritic spine morphology. Kalirin-7 can lead to increases in spine number (not shown) and size downstream of transsynaptic signaling induced by ephrinB stimulation of EphB receptors (on left) and/or enhanced neuronal activity (on right). During activation of EphB, kalirin-7 is recruited and activates Rac1, leading to Pak-dependent actin polymerization. Neurotransmitter release activating NMDA receptors results in kalirin-7-mediated Rac1-dependent actin polymerization and synaptic AMPAR insertion. In both scenarios, actin polymerization leads to spine enlargement.
See this image and copyright information in PMC

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