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Comment
. 2009 May;11(5):540-2.
doi: 10.1038/ncb0509-540.

SCAI blocks MAL-evolent effects on cancer cell invasion

Rudy Juliano
Comment

SCAI blocks MAL-evolent effects on cancer cell invasion

Rudy Juliano. Nat Cell Biol. 2009 May.

Abstract

SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of beta1-integrins and loss of invasive potential.

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