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Case Reports
. 2009 Oct;95(1):71-80.
doi: 10.1007/s11060-009-9893-5. Epub 2009 Apr 30.

Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation

Aparna Govindan  1 , A Mahadevan  2 , D I Bhat  3 , A Arivazhagan  3 , Shrijeet Chakraborti  1 , M S Suja  1 , A A Phalguni  4 , S Sampath  3 , B A Chandramouli  3 , S K Shankar  1
Affiliations
Case Reports

Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation

Aparna Govindan et al. J Neurooncol. 2009 Oct.

Abstract

Papillary glioneuronal tumors are newly recognized seizure producing tumors. We report two such cases with immunohistochemical characterization of glial and neuronal components and briefly review literature. Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation.

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