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. 1991 Nov;164(5):969-72.
doi: 10.1093/infdis/164.5.969.

Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets

C Sweet  1 , F G Hayden, K J Jakeman, S Grambas, A J Hay
Affiliations

Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets

C Sweet et al. J Infect Dis. 1991 Nov.

Abstract

The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.

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